Furthermore, the analysis of the inheritance of RFLPs associated with each gene in recombinant inbred strains of mice showed that the 2 loci, symbolized Il-1a and Il-1b, are tightly linked and lie approximately 4.7 cM distal to beta-2-microglobulin. (1987) demonstrated that the 2 polypeptides of IL1, alpha and beta, are coded by mouse chromosome 2. By Southern blot analysis of DNA from a hamster/mouse somatic cell hybrid, D'Eustachio et al. ( 1985, 1986) contrariwise, Le Beau and Rowley (1986) assigned IL1B to the end of 18q. Le Beau and Rowley (1986), using a probe presumably of the alpha form, found in situ hybridization to the same region, 2q13-q21, where the presumed IL1B probe was assigned by Webb et al. Presumably this is the beta form of IL1 because the deduced molecular weight was 30,747. By in situ hybridization they localized it to q13-q21. ( 1985, 1986) assigned the IL1 gene to chromosome 2.
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